the method of delivery:
Topicals are cannabis-infused lotions, balms, bath salts and oils that are absorbed through the skin for localized relief of pain, soreness, and inflammation. Topicals are often chosen by patients who want the therapeutic benefits of marijuana without the cerebral euphoria associated with other delivery methods. They’re non-intoxicating, meaning Cannabinoids are absorbed through the skin but do not enter the bloodstream and are non-psychoactive.
HOW DO MARIJUANA-INFUSED TOPICALS WORK?
Cannabis-infused lotions, salves, oils, sprays, bath salts and other transdermal methods of relief work by binding to a network of receptors called CB2. These CB2 receptors are found throughout the body and are activated either by the body’s naturally-occurring endocannabinoids or by cannabis compounds known as “phytocannabinoids” (e.g., THC, CBD).
Even if a topical contains active THC, it still won’t induce that intense “high” you’d get from smoking or ingesting cannabis. With most topicals, cannabinoids can’t breach the bloodstream; they only penetrate to the system of CB2 receptors.